ID | 113857 |
Author |
Bando, Hiroshi
Tokushima University|Japan Low Carbohydrate Diet Promotion Association
KAKEN Search Researchers
Ebe, Koji
Japan Low Carbohydrate Diet Promotion Association|Takao Hospital
Muneta, Tetsuo
Japan Low Carbohydrate Diet Promotion Association|Muneta Maternity Clinic
Bando, Masahiro
Tokushima University
Yonei, Yoshikazu
Doshisha University
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Keywords | calorie restricted diet (CRD)
glutamic acid decarboxylase (GAD)
latent autoimmune diabetes in adults (LADA)
low-carbohydrate diet (LCD)
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Content Type |
Journal Article
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Description | Background: Authors have continued research for meal tolerance test (MTT) by calorie restriction diet (CRD) and low carbohydrate diet (LCD), besides M value and glucose variability.
Methods: Subjects were 38 patients of two groups. Group-1 has 19 patients (57.6±12.9 years) with type 2 diabetes mellitus (T2DM) and positive glutamic acid decarboxylase antibody (GADA), which is possible to latent autoimmune diabetes in adults (LADA). Group-2 has recruited 19 cases with T2DM and negative GADA, who showed age, sex, glucose variability-matched subjects. They were given CRD on day 1-2, and LCD day 3-14, and biomarkers were compared between Group-1 and Group-2. Results: Average values of the daily profile of blood glucose on day2(CRD)/day4(LCD) in Group-1 vs 2 were studied. Obtained data were 202/148 mg/dL vs 205/143 mg/dL, respectively with similarity. However, M value showed 174/58 vs 179/22, respectively with difference. There were significant correlations of M value between day2 and day4 in Group-1 vs Group-2. Further, both showed contrast tendency, associated with wide distribution vs narrow distribution, respectively. Conclusions: These results suggested that Group-1 with positive GADA may have insufficient pancreas secretion compared with that of Group-2, and these data may become a basal reference for future study of LADA. |
Journal Title |
International Medicine
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ISSN | 26677008
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Publisher | International Medicine
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Volume | 1
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Issue | 3
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Start Page | 124
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End Page | 133
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Published Date | 2019
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Rights | This is an Open Access article under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/)
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DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
Publisher
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departments |
Medical Sciences
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