number of access : ?
number of downloads : ?
ID 114034
Title Alternative
Definite ECRS diagnosis with systemic steroid
Author
Fujimoto, Chisa Yoshinogawa Medical Center|Tokushima Municipal Hospital
Tamura, Koichi Tokushima Municipal Hospital KAKEN Search Researchers
Takaishi, Shizuka Tokushima Municipal Hospital
Kawata, Ikuji Yoshinogawa Medical Center
Keywords
eosinophilic chronic rhinosinusitis (ECRS)
chronic rhinosinusitis with nasal polyps
preoperative systemic steroids
endoscopic sinus surgery (ESS)
Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC)
Content Type
Journal Article
Description
According to JESREC criteria, definite eosinophilic chronic rhinosinusitis (ECRS) is postoperatively diagnosed based on over 70 eosinophils in high power magnification fields of the resected nasal polyps in patients with probable ECRS. Preoperative systemic administration with steroid is a standard practice, because it reduced intraoperative bleeding during endoscopic sinus surgery (ESS) in patients with ECRS. However, it was recently reported that systemic administration with steroid decreased the number of eosinophils in the nasal polyps, leading to a false negative diagnosis of definite ECRS. To overcome the risk, we have adopted short-term pre-operative systemic administration with low-dose of steroid and examined if our steroid administration makes a false-negative diagnosis. We performed a retrospective chart review of 42 patients with probable ECRS. Eleven patients were administered with 0.5 mg of bethametasone for 7 days before ESS, and other 31 patients were not administered. The average number of eosinophils in nasal polyps in patients who were administered with steroid was 188 ± 167, which was not different from 199 ± 149 in the patients who were not administered. These findings suggest that short-term preoperative administration with low-dose of steroid has few risk of a false-negative diagnosis of definite ECRS.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA12022913
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
66
Issue
3-4
Start Page
233
End Page
236
Sort Key
233
Published Date
2019-08
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
University Hospital
Medical Sciences