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ID 113960
Title Alternative
先天性心疾患の小児における光干渉断層撮影法を用いた肺動脈壁厚と肺循環動態の関連についての検討
PA Thickening on OCT in Children With CHD
Author
Ono, Akemi University of Tokushima
Keywords
Children
Congenital heart disease
Optical coherence tomography
Pulmonary arterial hypertension
Content Type
Thesis or Dissertation
Description
Background: Pulmonary arterial (PA) wall thickening evaluated by optical coherence tomography (OCT) has been reported in adults with PA hypertension. The purpose of this study was to evaluate the feasibility of OCT for preoperative assessment of the PA wall in children with congenital heart disease (CHD).
Methods and Results: Participants comprised 39 patients with ventricular septal defect, atrial septal defect, or patent ductus arteriosus. Attempts were made to evaluate vessels of various diameters using OCT. Clearly observed vessels that were optimal for evaluation were selected and classified into 4 subgroups by diameter of the lumen. Optimal depiction was obtained in 80 of 156 vessels in total, and 25 (64.1%), 34 (87.1%), 17 (43.6%), and 4 vessels (10.3%) in each of the 1.0–<2.0 mm, 2.0–<3.0 mm, 3.0–<4.0 mm, and 4.0–5.0 mm subgroups, respectively. Arterial walls in the 2.0–<3.0 mm subgroup were the most frequently delineated, and wall thickness correlated significantly with mean PA pressure, pulmonary vascular resistance index, pulmonary-to-systemic flow ratio, and PA capacitance index (r=0.56, 0.52, 0.37, and −0.49, respectively). The 3-layered appearance was delineated in 29 of 80 vessels (36.2%). This feature had no significant correlation with pulmonary hemodynamics.
Conclusions: OCT represents a promising tool for evaluating the PA wall in children with CHD.
Journal Title
Circulation Journal
ISSN
13469843
13474820
NCID
AA11591968
Publisher
The Japanese Circulation Society
Volume
82
Issue
9
Start Page
2350
End Page
2357
Published Date
2018-08-24
Remark
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Yukako Hommaの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3498号
Diploma Number
甲医第1484号
Granted Date
2021-03-23
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences