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ID 113960
タイトル別表記
先天性心疾患の小児における光干渉断層撮影法を用いた肺動脈壁厚と肺循環動態の関連についての検討
PA Thickening on OCT in Children With CHD
著者
本間, 友佳子 徳島大学大学院医科学教育部(医学専攻) 徳島大学 教育研究者総覧
Ono, Akemi University of Tokushima
キーワード
Children
Congenital heart disease
Optical coherence tomography
Pulmonary arterial hypertension
資料タイプ
学位論文
抄録
Background: Pulmonary arterial (PA) wall thickening evaluated by optical coherence tomography (OCT) has been reported in adults with PA hypertension. The purpose of this study was to evaluate the feasibility of OCT for preoperative assessment of the PA wall in children with congenital heart disease (CHD).
Methods and Results: Participants comprised 39 patients with ventricular septal defect, atrial septal defect, or patent ductus arteriosus. Attempts were made to evaluate vessels of various diameters using OCT. Clearly observed vessels that were optimal for evaluation were selected and classified into 4 subgroups by diameter of the lumen. Optimal depiction was obtained in 80 of 156 vessels in total, and 25 (64.1%), 34 (87.1%), 17 (43.6%), and 4 vessels (10.3%) in each of the 1.0–<2.0 mm, 2.0–<3.0 mm, 3.0–<4.0 mm, and 4.0–5.0 mm subgroups, respectively. Arterial walls in the 2.0–<3.0 mm subgroup were the most frequently delineated, and wall thickness correlated significantly with mean PA pressure, pulmonary vascular resistance index, pulmonary-to-systemic flow ratio, and PA capacitance index (r=0.56, 0.52, 0.37, and −0.49, respectively). The 3-layered appearance was delineated in 29 of 80 vessels (36.2%). This feature had no significant correlation with pulmonary hemodynamics.
Conclusions: OCT represents a promising tool for evaluating the PA wall in children with CHD.
掲載誌名
Circulation Journal
ISSN
13469843
13474820
cat書誌ID
AA11591968
出版者
The Japanese Circulation Society
82
9
開始ページ
2350
終了ページ
2357
発行日
2018-08-24
備考
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Yukako Hommaの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3498号
学位記番号
甲医第1484号
学位授与年月日
2021-03-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系