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ID 116788
Author
Imoto, Issei Aichi Cancer Center Research Institute KAKEN Search Researchers
Nakano, Yasutaka Shiga University of Medical Science
Kusumoto, Masahiko National Cancer Center Hospital
Kaneko, Masahiro Tokyo Health Service Association
Keywords
Emphysema
single nucleotide polymorphism
computed tomography
longitudinal follow-up study
Content Type
Journal Article
Description
Chronic obstructive pulmonary disease (COPD) is predicted to become the third leading cause of death worldwide by 2030. Smoking is a well-known risk factor in the development of COPD. Association between COPD genes and smoking have been studied. This paper presents an association analysis of single nucleotide polymorphisms (SNPs) with a CT image-based phenotype of emphysema progression in heavy smokers. The emphysema progression was quantitatively represented by the annual increment of low attenuation volume (LAV) on CT scans for five years. 10 candidate SNPs were selected from 316 SNPs in 125 papers of genetic studies of COPD and lung cancer. The genotypes were determined by real-time polymerase chain reaction (PCR) using deoxyribonucleic acid (DNA) extracted from saliva samples. The association analysis was performed by Fisher's exact test and logistic regression analysis. This method was applied to a dataset with 144 participants (71 smokers, 61 past smokers, and 12 non-smokers). The results showed that the genotypes of rs3923564 and rs13180 SNPs were candidate SNPs associated with the CT image based-emphysema progression.
Journal Title
Proceedings of SPIE
ISSN
0277786X
NCID
AA10619755
Publisher
SPIE
Volume
11314
Start Page
113142D
Published Date
2020-03-16
Remark
Hidenobu Suzuki, Mikio Matsuhiro, Yoshiki Kawata, Noboru Niki, Issei Imoto, Yasutaka Nakano, Masahiko Kusumoto, and Masahiro Kaneko "Association analysis of SNPs with CT image-based phenotype of emphysema progression in heavy smokers", Proc. SPIE 11314, Medical Imaging 2020: Computer-Aided Diagnosis, 113142D (16 March 2020); https://doi.org/10.1117/12.2549431
Rights
Copyright 2020 Society of Photo-Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
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language
eng
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departments
Science and Technology
Medical Sciences