The antitumor activity of xanthohumol
Shikata, Yuki Keio University
Yoshimaru, Tetsuro Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Komatsu, Masato Tokushima University
Katoh, Hiroto Tokyo Medical and Dental University|JST
Sato, Reiko Tokyo Medical and Dental University
Kanagaki, Shuhei Keio University
Okazaki, Yasumasa Nagoya University
Toyokuni, Shinya Nagoya University
Tashiro, Etsu Keio University
Ishikawa, Shumpei Tokyo Medical and Dental University
Katagiri, Toyomasa Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Imoto, Masaya Keio University
Xanthohumol (XN), a simple prenylated chalcone, can be isolated from hops and has the potential to be a cancer chemopreventive agent against several human tumor cell lines. We previously identified valosin-containing protein (VCP) as a target of XN; VCP can also play crucial roles in cancer progression and prognosis. Therefore, we investigated the molecular mechanisms governing the contribution of VCP to the antitumor activity of XN. Several human tumor cell lines were treated with XN to investigate which human tumor cell lines are sensitive to XN. Several cell lines exhibited high sensitivity to XN both in vitro and in vivo. shRNA screening and bioinformatics analysis identified that the inhibition of the adenylate cyclase (AC) pathway synergistically facilitated apoptosis induced by VCP inhibition. These results suggest that there is crosstalk between the AC pathway and VCP function, and targeting both VCP and the AC pathway is a potential chemotherapeutic strategy for a subset of tumor cells.
Japanese Cancer Association
© 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.
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Institute of Advanced Medical Sciences