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ID 112374
タイトル別表記
The antitumor activity of xanthohumol
著者
Shikata, Yuki Keio University
小松, 正人 Tokushima University
Katoh, Hiroto Tokyo Medical and Dental University|JST
Sato, Reiko Tokyo Medical and Dental University
Kanagaki, Shuhei Keio University
Okazaki, Yasumasa Nagoya University
Toyokuni, Shinya Nagoya University
Tashiro, Etsu Keio University
Ishikawa, Shumpei Tokyo Medical and Dental University
Imoto, Masaya Keio University
キーワード
Adenylate cyclase
antitumor activity
apoptosis
valosin-containing protein
xanthohumol
資料タイプ
学術雑誌論文
抄録
Xanthohumol (XN), a simple prenylated chalcone, can be isolated from hops and has the potential to be a cancer chemopreventive agent against several human tumor cell lines. We previously identified valosin-containing protein (VCP) as a target of XN; VCP can also play crucial roles in cancer progression and prognosis. Therefore, we investigated the molecular mechanisms governing the contribution of VCP to the antitumor activity of XN. Several human tumor cell lines were treated with XN to investigate which human tumor cell lines are sensitive to XN. Several cell lines exhibited high sensitivity to XN both in vitro and in vivo. shRNA screening and bioinformatics analysis identified that the inhibition of the adenylate cyclase (AC) pathway synergistically facilitated apoptosis induced by VCP inhibition. These results suggest that there is crosstalk between the AC pathway and VCP function, and targeting both VCP and the AC pathway is a potential chemotherapeutic strategy for a subset of tumor cells.
掲載誌名
Cancer Science
ISSN
13497006
出版者
Japanese Cancer Association
108
4
開始ページ
785
終了ページ
794
発行日
2017-01-25
権利情報
© 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
先端酵素学研究所