Development of thiol-responsive amide bond cleavage device and its application for peptide nucleic acid-based DNA releasing system

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Use this link to cite this item : https://repo.lib.tokushima-u.ac.jp/111901

ID	111901
Author	Shigenaga, Akira The University of Tokushima KAKEN Search Researchers Yamamoto, Jun The University of Tokushima Hirakawa, Hiroko The University of Tokushima Ogura, Keiji The University of Tokushima Maeda, Nami The University of Tokushima Morishita, Ko The University of Tokushima Otaka, Akira The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Content Type	Journal Article
Description	To develop a thiol-responsive DNA releasing system, a thiol-responsive amino acid capable of inducing an amide bond cleavage in the presence of a thiol was developed. It was successfully combined with peptide nucleic acid (PNA), and thiol-induced release of DNA from the thiol-responsive PNA/DNA complex was observed.
Journal Title	Tetrahedron Letters
ISSN	00404039
NCID	AA00861801 AA11539822
Publisher	Elsevier Ltd.
Volume	51
Issue	18
Start Page	2525
End Page	2528
Published Date	2010-03-03
Rights	©2010. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID	206827
DOI (Published Version)	10.1016/j.tetlet.2010.03.006
URL ( Publisher's Version )	https://doi.org/10.1016/j.tetlet.2010.03.006
FullText File	tetlet_51_18_2525.pdf 313 KB tetlet_51_18_2525_si.pdf 145 KB
language	eng
TextVersion	Author
departments	Pharmaceutical Sciences