ID 110729
Author
Sun, Xue-Zhi Environmental and Toxicological Sciences Research Group, National Institute of Radiological Sciences
Takahashi, Sentaro Environmental and Toxicological Sciences Research Group, National Institute of Radiological Sciences
Kubota, Yoshihisa Environmental and Toxicological Sciences Research Group, National Institute of Radiological Sciences
Zhang, Rui Department of Anatomy and Developmental Neurobiology, The University of Tokushima School of Medicine
Cui, Chun Department of Anatomy and Developmental Neurobiology, The University of Tokushima School of Medicine
Nojima, Kumie Research Laboratory of Space Radiation, National Institute of Radiological Sciences
Fukui, Yoshihiro Department of Anatomy and Developmental Neurobiology, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
cerebral hemisphere
heavy-ion beam
irradiation
Content Type
Journal Article
Description
Heavy-ion beams have the feature to administer a large radiation dose in the vicinity of the endpoint in the beam range, its irradiation system and biophysical characteristics are different from ordinary irradiation instruments like X-rays or gamma-rays. In order to get clarify characteristic effects of heavy-ion beams on the brain, we have developed an experimental system for irradiating a restricted region of the rat brain using heavy-ion beams. The left cerebral hemispheres of the adult rat brain were irradiated at dose of 50Gy charged carbon particles (290MeV/nucleon 5mmspread-out Bragg peak). After irradiation, the characteristics of the heavy-ion beams and the animal model were studied. Histological examination and measurement showed that extensive necrosis was observed between 2.5mmand7.5mmdepth from the surface of the rat head, suggesting a relatively high dose and uniform dose was delivered among designed depths and the spread-out bragg peak used here successfully and satisfactorily retained its high-dose localization in the defined region. We believe that our experimental model for irradiating a restricted region of the rat brain using heavy-ion beams is a good model for analyzing regional radiation susceptibility of the brain.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
51
Issue
1-2
Start Page
103
End Page
107
Sort Key
103
Published Date
2004-02
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences