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ID 109381
Title Alternative
さまざまな身体活動レベルにおけるヒトの骨格筋量と筋力に対する食事性大豆たんぱく質の効果
Effect of soy protein on the muscle in human
Author
Hashimoto, Rie The University of Tokushima
Sakai, Atsuko The University of Tokushima
Murayama, Masumi The University of Tokushima
Ochi, Arisa The University of Tokushima
Abe, Tomoki The University of Tokushima KAKEN Search Researchers
Hirasaka, Katsuya The University of Tokushima|Nagasaki University KAKEN Search Researchers
Ohno, Ayako The University of Tokushima
Inatsugi, Mikiko Inatsugi Orthopedic Hospital
Doi, Daisuke Inatsugi Orthopedic Hospital
Takeda, Masanori Kyoritsu Hospital
Keywords
bedridden patients
casein
muscle volume
quadriceps femoris muscle
soy protein isolate
Content Type
Thesis or Dissertation
Description
Background : In recent years, the number of bedridden people is rapidly increasing due to aging or lack of exercise in Japan. This problem is becoming more serious, since there is no countermeasure against it. In the present study, we designed to investigate whether dietary proteins, especially soy, had beneficial effects on skeletal muscle in 59 volunteers with various physical activities. Methods : We subjected 59 volunteers with various physical activities to meal intervention examination. Persons with low and high physical activities were divided into two dietary groups, the casein diet group and the soy diet group. They ate daily meals supplemented with 7.8 g of powdered casein or soy protein isolate every day for 30 days. Bedridden patients in hospitals were further divided into three dietary groups : the no supplementation diet group, the casein diet group and the soy diet group. They were also subjected to a blood test, a urinalysis, magnetic resonance imaging analysis and muscle strength test of the knee before and after the meal intervention study. Results : Thirty-day soy protein supplementation significantly increased skeletal muscle volume in participants with low physical activity, compared with 30-day casein protein supplementation. Both casein and soy protein supplementation increased the volume of quadriceps femoris muscle in bedridden patients. Consistently, soy protein significantly increased their extension power of the knee, compared with casein protein. Although casein protein increased skeletal muscle volume more than soy protein in bedridden patients, their muscle strength changes by soy protein supplementation were bigger than those by casein protein supplementation. Conclusions : The supplementation of soy protein would be one of the effective foods which prevent the skeletal muscle atrophy caused by immobilization or unloading.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA12022913
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
62
Issue
3-4
Start Page
177
End Page
183
Sort Key
177
Published Date
2015-08
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201505251027.pdf
論文本文 : k2851_fulltext.pdf
本論文は,著者Rie Hashimotoの学位論文として提出され, 学位審査・授与の対象となっている。
著者の申請により要約(2015-05-26公開)に替えて論文全文を公開(2020-04-10)
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第2851号
Diploma Number
甲栄第229号
Granted Date
2015-03-26
Degree Name
Doctor of Nutritional Science
Grantor
Tokushima University
departments
Medical Sciences
University Hospital
Bioscience and Bioindustry