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ID 112235
Title Alternative
食道がん化学療法患者における漢方薬使用の効果 : 口腔衛生および口腔内状態に関する臨床研究
Kampo medicine for esophageal cancer treatment
Author
Moriyama, Satomi Tokushima University
Sogawa, Yuka Tokushima University
Grenier, Daniel Université Laval
Keywords
Kampo medicine
esophageal cancer
periodontopathogenic bacteria
gingival inflammation
Content Type
Thesis or Dissertation
Description
Objective : The aim of this study was to investigate the impact of the use of two Kampo medicines on oral mucositis, tongue coating bacteria, and gingiva condition in patients with esophageal cancer undergoing chemotherapy. Methods : Twenty-three esophageal cancer patients who receive chemotherapy at Tokushima University Hospital, were included. The participants, who received professional oral healthcare, were randomly divided into three groups : 7 subjects received Daiokanzoto sherbets, 7 subjects received Hangeshashinto sherbets, and 9 subjects received nothing (control). The numbers of total bacteria and specific periodontopathogenic bacteria in tongue coating were determined in addition to clinical parameters. Results : No difference on the onset of oral mucositis was found among the three groups. However, tongue coating index, gingival index (GI), plaque index, the number of total bacteria, Fusobacterium nucleatum and Campylobacter rectus were decreased during chemotherapy. More specifically, GI as well as the number of F. nucleatum and C. rectus were decreased significantly in the Daiokanzoto group when compared to the controlgroup (p<0.05). No such differences were observed for the group receiving Hangeshashinto. Conclusion : This clinical trial showed that Daiokanzoto might be effective in attenuating gingival inflammation and reducing the levels of periodontopathogenic bacteria in patients with esophageal cancer.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA12022913
AA11166929
Publisher
Faculty of Medicine Tokushima University
Volume
65
Issue
3-4
Start Page
184
End Page
190
Sort Key
184
Published Date
2018-08
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Satomi Moriyamaの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3374号
Diploma Number
甲口保第2号
Granted Date
2020-03-23
Degree Name
Doctor of Oral Health Science
Grantor
Tokushima University
departments
Oral Sciences
University Hospital
Medical Sciences