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ID 112235
タイトル別表記
食道がん化学療法患者における漢方薬使用の効果 : 口腔衛生および口腔内状態に関する臨床研究
Kampo medicine for esophageal cancer treatment
著者
森山, 聡美 徳島大学大学院口腔科学教育部(口腔保健学専攻)
Sogawa, Yuka Tokushima University
Grenier, Daniel Université Laval
キーワード
Kampo medicine
esophageal cancer
periodontopathogenic bacteria
gingival inflammation
資料タイプ
学位論文
抄録
Objective : The aim of this study was to investigate the impact of the use of two Kampo medicines on oral mucositis, tongue coating bacteria, and gingiva condition in patients with esophageal cancer undergoing chemotherapy. Methods : Twenty-three esophageal cancer patients who receive chemotherapy at Tokushima University Hospital, were included. The participants, who received professional oral healthcare, were randomly divided into three groups : 7 subjects received Daiokanzoto sherbets, 7 subjects received Hangeshashinto sherbets, and 9 subjects received nothing (control). The numbers of total bacteria and specific periodontopathogenic bacteria in tongue coating were determined in addition to clinical parameters. Results : No difference on the onset of oral mucositis was found among the three groups. However, tongue coating index, gingival index (GI), plaque index, the number of total bacteria, Fusobacterium nucleatum and Campylobacter rectus were decreased during chemotherapy. More specifically, GI as well as the number of F. nucleatum and C. rectus were decreased significantly in the Daiokanzoto group when compared to the controlgroup (p<0.05). No such differences were observed for the group receiving Hangeshashinto. Conclusion : This clinical trial showed that Daiokanzoto might be effective in attenuating gingival inflammation and reducing the levels of periodontopathogenic bacteria in patients with esophageal cancer.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA12022913
AA11166929
出版者
Faculty of Medicine Tokushima University
65
3-4
開始ページ
184
終了ページ
190
並び順
184
発行日
2018-08
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Satomi Moriyamaの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3374号
学位記番号
甲口保第2号
学位授与年月日
2020-03-23
学位名
博士(口腔保健学)
学位授与機関
徳島大学
部局
歯学系
病院
医学系