number of access : ?
number of downloads : ?
ID 109961
Title Alternative
ホエーの長期間摂取が老齢ラット唾液腺の萎縮、遺伝子変化、機能低下に及ぼす効果
Author
Pieczonka, Tomasz Daniel Tokushima University
Bragiel, Aneta M Tokushima University
Horikawa, Hideaki Tokushima University
Fukuta, Kana cAPRO Life Science Institute Inc.
Keywords
Whey
Aging
DNA microarray
Salivary glands
Atrophy
Dysfunction
Content Type
Thesis or Dissertation
Description
Salivary glands in elderly individuals commonly exhibit morphological changes and dysfunction resulting in xerostomia. Long-term (4-week) drinking of whey prevented and/or restored age-dependent decline of salivary volume and protein concentration, and atrophy of sublingual glands (SLGs) significantly in 88-week-old rats. The transcripts of 42 genes were up-regulated and 7 genes were down-regulated by more than 1.5-fold change with FDR ≦ 0.1 after whey-drinking. The expression levels of genes associated with salivary proteins and tissue repair were significantly increased, while those associated with lipid metabolism were decreased. Venn diagram analysis revealed that expressions of 13 genes, including Tcfap2b and Abpa, were induced significantly by whey-drinking. Furthermore, secretory protein levels in SLGs and saliva were revealed by immunoblot analysis. This is the first study to report that whey-administration can prevent and/or restore age-dependent atrophy and functional decline of SLGs in relation to gene expression and thus may serve as a functional food ingredient.
Journal Title
Journal of Functional Foods
ISSN
17564646
Publisher
Elsevier
Volume
21
Start Page
349
End Page
358
Published Date
2016-01-04
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨 : LID201611151001.pdf
審査要旨 : LID201611151002.pdf
論文本文 : LID201702061004.pdf
著者の申請により要約(2016-11-15公開)に替えて論文本文を公開(2017-02-06)
本論文は, 著者Tomasz D Pieczonkaの学位論文として提出され, 学位審査・授与の対象となっている。
Rights
© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第2978号
Diploma Number
甲口第412号
Granted Date
2016-09-23
Degree Name
Doctor of Philosophy
Grantor
Tokushima University
departments
Oral Sciences