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ID 109961
タイトル別表記
ホエーの長期間摂取が老齢ラット唾液腺の萎縮、遺伝子変化、機能低下に及ぼす効果
著者
ペクゾンカ, トーマス ダニエル 徳島大学大学院口腔科学教育部(口腔科学専攻)
Bragiel, Aneta M Tokushima University
Horikawa, Hideaki Tokushima University
Fukuta, Kana cAPRO Life Science Institute Inc.
キーワード
Whey
Aging
DNA microarray
Salivary glands
Atrophy
Dysfunction
資料タイプ
学位論文
抄録
Salivary glands in elderly individuals commonly exhibit morphological changes and dysfunction resulting in xerostomia. Long-term (4-week) drinking of whey prevented and/or restored age-dependent decline of salivary volume and protein concentration, and atrophy of sublingual glands (SLGs) significantly in 88-week-old rats. The transcripts of 42 genes were up-regulated and 7 genes were down-regulated by more than 1.5-fold change with FDR ≦ 0.1 after whey-drinking. The expression levels of genes associated with salivary proteins and tissue repair were significantly increased, while those associated with lipid metabolism were decreased. Venn diagram analysis revealed that expressions of 13 genes, including Tcfap2b and Abpa, were induced significantly by whey-drinking. Furthermore, secretory protein levels in SLGs and saliva were revealed by immunoblot analysis. This is the first study to report that whey-administration can prevent and/or restore age-dependent atrophy and functional decline of SLGs in relation to gene expression and thus may serve as a functional food ingredient.
掲載誌名
Journal of Functional Foods
ISSN
17564646
出版者
Elsevier
21
開始ページ
349
終了ページ
358
発行日
2016-01-04
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨 : LID201611151001.pdf
審査要旨 : LID201611151002.pdf
論文本文 : LID201702061004.pdf
著者の申請により要約(2016-11-15公開)に替えて論文本文を公開(2017-02-06)
本論文は, 著者Tomasz D Pieczonkaの学位論文として提出され, 学位審査・授与の対象となっている。
権利情報
© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第2978号
学位記番号
甲口第412号
学位授与年月日
2016-09-23
学位名
博士(学術)
学位授与機関
徳島大学
部局
歯学系