ID | 113964 |
Title Alternative | RV Stiffness and Relaxation in PAH
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Author |
Hayabuchi, Yasunobu
Tokushima University
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Kagami, Shoji
Tokushima University
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Keywords | Right ventricle
Diastolic function
Pulmonary arterial hypertension
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Content Type |
Journal Article
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Description | We hypothesized that the kinematic model-based parameters obtained from the transtricuspid E-wave would be useful for evaluating RV diastolic property in pediatric pulmonary arterial hypertension (PAH) patients. The model was parametrized by stiffness/elastic recoil k, relaxation/damping c, and load x. These parameters were determined as the solution of m⋅d2x/dt2 + c⋅dx/dt + kx = 0, which is based on the theory that the E-wave contour is determined by the interplay of stiffness/restoring force, damping/relaxation force, and load. The PAH group had a significantly higher k and c versus the control group (182.5 ± 72.4 g/s2 vs. 135.7 ± 49.5 g/s2, p = 0.0232 and 21.9 ± 6.5 g/s vs. 10.6 ± 5.2 g/s, p <0.0001, respectively). These results show that RV has a higher stiffness/elastic recoil and inferior cross-bridge relaxation in the PAH group. Present findings indicate the feasibility and utility of kinematic model parameters for assessing RV diastolic function.
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Journal Title |
Ultrasound in Medicine and Biology
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ISSN | 03015629
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NCID | AA00876354
AA11541187
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Publisher | Elsevier|World Federation for Ultrasound in Medicine and Biology
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Volume | 45
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Issue | 8
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Start Page | 1999
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End Page | 2009
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Published Date | 2019-05-20
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Rights | © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
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DOI (Published Version) | |
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language |
eng
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TextVersion |
Author
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departments |
Medical Sciences
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