ID 101799
タイトルヨミ
ワクチン カイハツ ノ シンセンリャク ト コンゴ ノ ホウコウセイ
タイトル別表記
New vaccine development strategies
著者
岸原, 健二 徳島大学大学院ヘルスバイオサイエンス研究部先端医療創生科学講座生体防御医学分野
キーワード
vaccine development
DNA vaccine
DISC vaccine
hybrid vaccine
mucosal vaccine
資料タイプ
学術雑誌論文
抄録
There are still many infectious diseases for which we lack effective vaccines. A vaccine such as measles or polio can be used effectively in developing countries, where mortality from these diseases is still high. The development of vaccines therefore remains an important goal of immunology and recently we saw a shift to a more rational approach, based on a detailed molecular understanding of microbial, viral and parasitic pathogenecity, analysis of the protective host response to pathogenic organisms, and the understanding of the regulation of the immune system to generate effective Tand B-lymphocyte responses. Thus, modern technologies offer rational strategies for the development of new and important vaccines against diseases of public health importance. In this review, such new strategies for vaccine development are introduced, which include recombinant bacterial/viral vaccines, hybrid(chimera)vaccines, subunit vaccines, conjugate vaccines, DISC vaccines, reverse vaccinology, DNA vaccines, dendritic cell vaccines, Heterologous prime-boost vaccination strategy, mucosal vaccines and so on. On the other hand, financial and bioethical impediments make some of the most complicated problems for the realization of the full application of the new technologies in developing countries where many people are still suffering from infectious diseases. We also need to consider and discuss such aspects of vaccine development.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
60
5-6
開始ページ
133
終了ページ
139
並び順
133
発行日
2004-12-20
備考
フルテキストファイル
言語
jpn