ID | 106376 |
タイトル別表記 | 関心領域自動設定システムを用いた磁気共鳴動脈タギング撮像法と単一光子放射断層撮影における脳灌流定量画像の比較
Comparison of CBF between pCASL and SPECT
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著者 |
岩永, 崇
徳島大学大学院保健科学教育部(保健学専攻)
Funakoshi, Yasuhiro
The University of Tokushima
Kunikane, Yamato
Tokushima University
Matsuda, Tsuyoshi
GE Healthcare Japan Corporation
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キーワード | arterial spin labeling
iodine-123-N-isopropyl-p-iodoamphetamine
pulsed continuous arterial spin labeling
regional cerebral blood flow
3-dimensional stereotactic region-of-interest software
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資料タイプ |
学位論文
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抄録 | Purpose: We compared the regional cerebral blood flow (rCBF) obtained by pulsed continuous arterial spin labeling (pCASL) and iodine-123-N-isopropyl-p-iodoamphetamine (IMP) single photon emission computed tomography (SPECT) using 3-dimensional stereotactic region-of-interest (ROI) software for automated definition of ROIs in anatomic regions of the brain.
Methods: Thirteen patients with cerebrovascular occlusive disease and three with transient ischemic attacks underwent pCASL and IMP SPECT imaging. We compared rCBF values of each anatomic region and calculated the correlation coefficients between pCASL and IMP SPECT. We also calculated the asymmetry index (AI) using ROIs in contralateral regions of the hemispheres. Results: The rCBF values calculated from pCASL and IMP SPECT were comparable in most segments, but rCBF in the thalamus (P < 0.0001) and hippocampus (P = 0.0006) was significantly higher measured by pCASL than IMP SPECT. The correlation of rCBF between pCASL and IMP SPECT in the affected hemisphere (r = 0.50) tended to be lower than that in the normal hemisphere (r = 0.59), but not significantly different (P = 0.25). Moreover, there was a fixed bias for underestimation of rCBF by pCASL (P = 0.0047) in the affected hemisphere. The calculated AI showed a significant relationship between methods (r = 0.79, P < 0.0001). Conclusion: The rCBF obtained by pCASL had positive relationships with IMP SPECT. However, it should be considered that pCASL tends to have a weak relationship with IMP SPECT in some normal regions and regions affected by cerebrovascular occlusive disease. |
掲載誌名 |
Magnetic Resonance in Medical Sciences
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ISSN | 18802206
13473182
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cat書誌ID | AA12036292
AA11648770
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出版者 | Japanese Society for Magnetic Resonance in Medicine
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巻 | 13
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号 | 4
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開始ページ | 239
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終了ページ | 249
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発行日 | 2014-12-01
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備考 | 内容要旨・審査要旨・論文本文の公開:
内容要旨 : LID201502041001.pdf 審査要旨 : LID201502041002.pdf 論文本文 : LID201502041003.pdf 本論文は, 著者Takashi IWANAGAの学位論文として提出され, 学位審査・授与の対象となっている。 |
出版社版DOI | |
出版社版URL | |
フルテキストファイル | |
言語 |
eng
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著者版フラグ |
博士論文全文を含む
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文科省報告番号 | 甲第2781号
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学位記番号 | 甲保第10号
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学位授与年月日 | 2014-11-20
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学位名 |
博士(保健学)
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学位授与機関 |
徳島大学
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部局 |
医学系
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