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ID 109408
タイトル別表記
歯周炎と2型糖尿病患者の歯肉溝滲出液中グリコアルブミンおよびカルプロテクチンレベルの研究
Glycated albumin level in GCF from diabetes patients
Glycated Albumin in Gingival Crevicular Fluid from Patients With Diabetes
著者
梶浦, 由加里 徳島大学大学院口腔科学教育部(口腔科学専攻) KAKEN研究者をさがす
キーワード
Diabetes
Diagnosis
Gingival crevicular fluid
Periodontal medicine
Calprotectin
diabetes mellitus
periodontics
資料タイプ
学位論文
抄録
Background: Diabetes mellitus (DM) patients have a high prevalence of periodontitis. DM-associated periodontitis (DM-P) is characterized by severe inflammation and tissue destruction. To diagnose DM-P is important for cures of periodontitis and DM. The purpose of this study was to investigate the levels of glycated albumin (GA), a DM marker, and calprotectin, an inflammatory marker, in gingival crevicular fluid (GCF) from patients with periodontitis and DM.
Methods: Seventy-eight subjects participated in this study were the patients with DM, chronic periodontitis (CP), DM-P and healthy individuals (H). GCF and blood were collected from four groups. GA and calprotectin in GCF were analyzed using western blotting and ELISA, and their levels were compared among H, DM, CP, and DM-P groups. GA and glycated hemoglobin (HbA1c) in blood were determined, and the correlation between GCF GA level and blood HbA1c or GA level was investigated. ROC analysis for GCF GA level to predict DM was performed.
Results: GA was identified in GCF, and its amount and concentration in GCF samples from DM and DM-P were significantly higher than those of non-DM groups (H and CP). Calprotectin amount in GCF from CP and DM-P was significantly higher than that in H and DM groups. GCF GA level was positively correlated to blood HbA1c and GA level. ROC analysis of GCF GA level showed an optimal cut-off value to predict DM.
Conclusions: GA showed a high level in GCF from DM patients. GA and calprotectin in GCF may be useful markers to diagnose DM-associated periodontitis.
掲載誌名
Journal of Periodontology
ISSN
00223492
19433670
cat書誌ID
AA00704406
AA00704417
出版者
Wiley|American Academy of Periodontology
85
12
開始ページ
1667
終了ページ
1675
発行日
2014-12-01
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨 : LID201506111001.pdf
審査要旨 : LID201506111002.pdf
論文本文 : LID201601181001.pdf
本論文は, 著者Yukari Kajiuraの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第2806号
学位記番号
甲口第388号
学位授与年月日
2015-03-23
学位名
博士(歯学)
学位授与機関
徳島大学
部局
歯学系
病院