ID 109552
著者
タグチ, カヨ Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
奥村(山中), 仙示 Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
ミズノ, アキラ Department of Clinical Biology and Medicine, Institute of Health Biosciences,University of Tokushima Graduate School
ナカムラ, タキ Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School
島田, 光生 Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
土井, 俊夫 Department of Clinical Biology and Medicine, Institute of Health Biosciences,University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
武田, 英二 Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
nutritional assessment
liver cirrhosis
hyperinsulinemic euglycemic clamp combined with oral glucose load
indirect calorimetry
diabetes mellitus
資料タイプ
学術雑誌論文
抄録
Glucose intolerance characterized by postprandial hyperglycemia and hyperinsulinemia
is commonly seen in patients with liver cirrhosis (LC). The aim of this study
is to clarify the relation between glucose intolerance and disorder of liver function in
patients with LC. The 75 g oral glucose tolerance test (75 g OGTT) and the hyperinsulinemic
euglycemic clamp combined with 0.2 g/kg oral glucose load (HECGL) were conducted
in 61 patients with LC. Based on the results of 75 g OGTT, the 61 patientswith LCwere divided
into groups, 21 (34.4%) patients with normal glucose tolerance (LC-NGT), 12 (19.7%)
patients with impaired glucose tolerance (LC-IGT) and 28 (45.9%) patients with diabetes
mellitus (LC-DM). Fasting plasma glucose (FPG) level was normal in 50 (82.0%) patients
with LC. All patients with LC showed insulin resistance in both peripheral (skeletal and
adipose) and hepatic tissues evaluated by HECGL, although significant correlation between
the degree of glucose intolerance and the severity of hepatic dysfunction was not observed.
Insulin resistance in both liver and peripheral tissues is the early sign in the patients with
LC. This fact indicates that nutritional care from early stages of LC would be necessary in
the patients.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
61
1-2
開始ページ
180
終了ページ
189
並び順
180
発行日
2014-02
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系