直近一年間の累計
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ID 109610
タイトルヨミ
セイジン Tサイボウ ハッケツビョウ ノ チリョウ
タイトル別表記
How to treat Adult T-cell leukemia
著者
武本, 重毅 国立病院機構熊本医療センター臨床検査科|熊本大学大学院医学教育部臨床国際協力学分野
キーワード
ATL
HTLV‐1
allogeneic stem cell transplantation
CCR4
資料タイプ
学術雑誌論文
抄録
Since Takatsuki’s group noticed a new disease, adult T-cell leukemia (ATL), caused by retroviral infection, many researchers tried to figure out how to prevent the transmission and how to treat the neoplasm of mature T lymphocyte for 35 years. Blood borne infection was controlled and stopped after the screening of HTLV‐1 antibody started in 1986. However, once HTLV‐1 carriers develop to aggressive type of ATL including acute type and lymphoma-type, the median survival time is about one year and the patients relapse and die even during chemotherapy. It has been hard time for patients and families more than 25 years. Then, over the last 10 years, nation-wide studies resulted in the progression of treatment strategy for improvement of ATL patients’ survival. One is allogeneic stem cell transplantation undergone in patients available for and the other is a novel monoclonal antibody against chemokine receptor CCR4 on the surface of ATL cells. The new era of ATL treatment has come. Furthermore, novel predictive marker of ATL development and biomarker of ATL treatment are investigated to release patients from this incurable disease.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
69
1-2
開始ページ
29
終了ページ
32
並び順
29
発行日
2013-04-25
フルテキストファイル
言語
jpn
著者版フラグ
出版社版