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ID 109701
タイトル別表記
肺癌同所移植モデルマウスの経時的評価における小動物用呼吸同期PET/CTの有用性
著者
大谷, 環樹 徳島大学大学院保健科学教育部(保健学専攻) 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Nagata, Motoi The University of Tokushima
Kishida, Mina The University of Tokushima
キーワード
Respiratory-gated PET/CT
Small animals
Orthotopic lung cancer
18F-FDG
資料タイプ
学位論文
抄録
Our aim in this study was to clarify the effects of respiratory-gated PET in the evaluation of lung cancer according to the 18F-FDG uptake in an orthotopic transplantation mouse model. We created such a model, and we performed PET/CT. The mice were divided into two groups according to tumor volume: a small-tumor group (<20 mm3) and a large-tumor group (>20 mm3). We reconstructed the following conditions based on list-mode data: non-gated (3D) images and gated (4D) images, divided based on the respiratory cycle (expiration phase, stable phase, and inspiration phase). We calculated the maximum standardized uptake values (SUVmax) in each phase. We used the % difference [= (4D SUVmax – 3D SUVmax)/3D PET SUVmax × 100 (%)] to evaluate the differences in the 4D SUVmax and 3D SUVmax. The 4D SUVmax values were significantly higher than the 3D SUVmax, regardless of the tumor size. The % difference for the small tumors was greater than that for the large tumors, and it was highest in the stable phase. We conclude that the SUVmax in the stable phase under respiratory-gated PET are the most reliable. The SUVmax observed under non-gated PET are considered to be more frequently underestimated in cases involving small tumors than in those involving large tumors. In the chronologic study evaluating the time course of tumor development, the size of the tumor is small in early stage, and respiratory-gated PET is effective in reducing the underestimation of such tumors caused by respiratory motion.
掲載誌名
Radiological Physics and Technology
ISSN
18650333
18650341
cat書誌ID
AA12236881
出版者
Springer Japan
8
2
開始ページ
266
終了ページ
277
発行日
2015-04-29
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨 : LID201606131007.pdf
審査要旨 : LID201606131008.pdf
論文本文 : LID201704171011.pdf
著者の申請により要約(2016-06-13公開)に替えて論文本文を公開(2017-04-17)
本論文は, 著者Tamaki Otaniの学位論文として提出され, 学位審査・授与の対象となっている。
The final publication is available at Springer via https://doi.org/10.1007/s12194-015-0316-3
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第2912号
学位記番号
甲保第23号
学位授与年月日
2016-03-23
学位名
博士(保健学)
学位授与機関
徳島大学
部局
放射線総合センター
医学系