ID 109746
著者
伊藤, 博夫 Department of Preventive Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Orihuela-Campos, Rita Cristina Department of Preventive Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School
福井, 誠 Department of Preventive Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
伊藤, 博夫 Department of Preventive Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
資料タイプ
学術雑誌論文
抄録
The wound healing process attempts to restore the integrity and function of the injured tissue. Additionally, proinflammatory cytokines, growth factors, and oxidative stress play important roles in wound healing. The aim of this study was to determine whether hydrogen-rich water intake induces the activation of the Nrf2/antioxidant defense pathway in rat palatal tissue, thereby reducing systemic oxidative stress and proinflammatory cytokine levels and promoting healing-associated genes. A circular excisional wound was created in the oral palatal region, and the wound healing process was observed.The rats were divided into two experimental groups in which either hydrogen-rich water or distilled water was consumed. In the drinking hydrogen-rich water, the palatal wound healing process was accelerated compared to that in the control group. As molecular hydrogen upregulated the Nrf2 pathway, systemic oxidative stresses were decreased by the activation of antioxidant activity. Furthermore, hydrogen-rich water intake reduced proinflammatory cytokine levels and promoted the expression of healing-associated factors in rat palatal tissue. In conclusion, hydrogen-rich water intake exhibited multiple beneficial effects through activation of the Nrf2/antioxidant defense pathway.The results of this study support the hypothesis that oral administration of hydrogen-rich water benefits the wound healing process by decreasing oxidative stress and inflammatory responses.
掲載誌名
Oxidative Medicine and Cellular Longevity
ISSN
19420900
cat書誌ID
AA12489832
2016
開始ページ
1
終了ページ
13
並び順
1
発行日
2016
備考
Copyright © 2016 Naofumi Tamaki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
EDB ID
出典
Oxidative Medicine and Cellular Longevity Volume 2016, Article ID 5679040, 13 pages http://dx.doi.org/10.1155/2016/5679040
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系