ID 109750
タイトルヨミ
ジヘイショウ ノ ノウガゾウ ケンキュウ
タイトル別表記
Neuroimaging study of autism
著者
森, 健治 徳島大学大学院ヘルスバイオサイエンス研究部子どもの保健・看護学分野 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
autism
proton magnetic resonance spectroscopy (1H-MRS)
amygdala
orbito-frontal cortex
資料タイプ
学術雑誌論文
抄録
Brothers proposed a network of neural regions that comprise the “social brain”, which includes the amygdala, the orbito-frontal cortex, and the superior temporal sulcus and gyrus. Since the psychiatric condition of autism involves deficits in “social intelligence”, it is plausible that autism may be caused by an abnormality of these regions.
We measured chemical metabolites in the left amygdala and the bilateral orbito-frontal cortex, which are the main components of the social brain. We also examined the association between these metabolic findings and social abilities in subjects with autism. The study group included 77 autistic patients and age-matched 31 normal children. Conventional proton magnetic resonance spectra were obtained using the STEAM sequence with parameters of TR=5 sec and TE=15 msec by a 1.5-tesla clinical MRI system. We analyzed the concentrations of N-acetylaspartate (NAA), creatine/phosphocreatine (Cr), and choline-containing compounds (Cho) using LCModel (Ver.6.1). The concentrations of NAA in the left amygdala and the bilateral orbito-frontal cortex in autistic patients were significantly decreased compared to those in the control group. In the autistic patients, the NAA concentrations in these regions correlated with their social quotient. These findings suggest the presence of neuronal dysfunction in the amygdala and orbito-frontal cortex in autism.
The amygdala is thought to play a central role in associating sensory cues with their motivational and emotional significance. Schoenbaum et al. proposed models of amygdala-frontal interaction in which motivational and emotional significance, coded by the amygdala, is conveyed to the orbito-frontal cortex for the control of action. Dysfunction in the amygdala and orbito-frontal cortex may contribute to the pathogenesis of autism.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
70
1-2
開始ページ
25
終了ページ
30
並び順
25
発行日
2014-04-25
EDB ID
300962
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
医学系