フッ化ジアミンシリケートを利用した象牙質知覚過敏症治療法の開発

Dentin hypersensitivity is a common disease, the incidence is approximately 30% in the general population. However, knowledge is limited regarding the etiology of dentin hypersensitivity, and there is no consistent treatment method. Therefore, relationship between the etiology of dentin hypersensitivity and condition of plaque control was evaluated in vivo using the vital teeth of dogs. In the plaque control group, the average diameter of dentin tubules decreased over time. In contrast, the diameter of the dentin tubules increased in the non-plaque control group. These results demonstrate that the spontaneous recovery of hypersensitive teeth would be expected if proper plaque control is carried out. Therefore, it was concluded that plaque control plays a key role in the etiology of dentin hypersensitivity, as in the prevention of dental caries. From the above results, an ideal treatment method for dentin hypersensitivity seems to be to occlude dentin tubules with a calcium phosphate similar to natural calcification at the tooth surface by mineral deposition from saliva. Ammonium hexafluorosilicate [SiF: (NH4)2SiF6] solution was prepared to overcome the defect of diamine silver fluoride. Dentin tubules after SiF treatment were completely occluded with the silica-calcium phosphate precipitate, similar to natural remineralization; therefore, SiF treatment is useful for the treatment of dentin hypersensitivity. In addition, SiF treatment significantly increased acid resistance and improved the crystallinity in both enamel and dentin. It is concluded that SiF treatment is useful for the prevention of dental caries as well as dentin hypersensitivity.