ID 110158
著者
向井, 理恵 Department of Food Science, Institute of Health Biosciences, University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
ホリカワ, ヒトミ Department of Food Science, Institute of Health Biosciences, University of Tokushima Graduate School
フジクラ, ユタカ Department of Food Science, Institute of Health Biosciences, University of Tokushima Graduate School
カワムラ, トモユキ Department of Pharmaceutical Chemistry, Institute of Health Biosciences, University of Tokushima Graduate School
根本, 尚夫 Department of Pharmaceutical Chemistry, Institute of Health Biosciences, University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
二川, 健 Department of Nutritional Physiology, Institute of Health Biosciences, University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
寺尾, 純二 Department of Food Science, Institute of Health Biosciences, University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
資料タイプ
学術雑誌論文
抄録
Flavonoids have attracted considerable attention in relation to their effects upon health. 8-Prenylnaringenin (8-PN) is found in the common hop (Humulus lupulus) and assumed to be responsible for the health impact of beer consumption. We wanted to clarify the effects of prenylation on the physiological functions of dietary flavonoids by comparing the effects of 8-PN with that of intact naringenin in the prevention of disuse muscle atrophy using a model of denervation in mice. Consumption of 8-PN (but not naringenin) prevented loss of weight in the gastrocnemius muscle further supported by the lack of induction of the protein content of a key ubiquitin ligase involved in muscle atrophy, atrogin-1, and by the activation of Akt phosphorylation. 8-PN content in the gastrocnemius muscle was tenfold higher than that of naringenin. These results suggested that, compared with naringenin, 8-PN was effectively concentrated into skeletal muscle to exert its preventive effects upon disuse muscle atrophy. It is likely that prenylation generates novel functions for 8-PN by enhancing its accumulation into muscle tissue through dietary intake.
掲載誌名
PLOS ONE
ISSN
19326203
7
9
開始ページ
e45048
並び順
45048
発行日
2012-09-19
備考
Copyright:© 2012 Mukai et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
EDB ID
262514
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
生物資源系
薬学系
医学系