ID 110163
著者
ショウダ, カツトシ Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
イチカワ, ダイスケ Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
フジタ, ユウジ Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine|Department of Human Genetics, Graduate School of Biomedical Sciences, Tokushima University
増田, 清士 Department of Human Genetics, Graduate School of Biomedical Sciences, Tokushima University KAKEN研究者をさがす
ヒラモト, ヒデカズ Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
ハマダ, ジュンイチ Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
アリタ, トモヒロ Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
コニシ, ヒロタカ Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
コスガ, トシユキ Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
コマツ, シュウヘイ Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
シオザキ, アツシ Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
オカモト, カズマ Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
井本, 逸勢 Department of Human Genetics, Graduate School of Biomedical Sciences, Tokushima University 徳島大学 教育研究者総覧 KAKEN研究者をさがす
オオツジ, エイゴ Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
資料タイプ
学術雑誌論文
抄録
Recent comprehensive molecular subtyping of gastric cancer (GC) identified Epstein–Barr virus (EBV)-positive tumors as a subtype with distinct salient molecular and clinical features. In this study, we aimed to determine the potential utility of circulating cell-free EBV DNA as a biomarker for the detection and/or monitoring of therapeutic response in patients with EBV-associated gastric carcinoma (EBVaGC). The EBV genes-to-ribonuclease P RNA component H1 ratios (EBV ratios) in the GC tumors and plasma samples were determined by quantitative real-time polymerase chain reaction in 153 patients with GC, including 14 patients with EBVaGC diagnosed by the conventional method. Circulating cell-free EBV DNA was detected in 14 patients with GC: the sensitivity and specificity of detection were 71.4% (10/14) and 97.1% (135/139), respectively. Plasma EBV ratios were significantly correlated with the size of EBVaGC tumors, and the plasma EBV DNA detected before surgery in EBVaGC cases disappeared after surgery. Patients with EBVaGC may have a better prognosis, but circulating cell-free EBV DNA had no or little impact on prognosis. In addition, repeated assessment of the plasma EBV ratio in EBVaGC showed a decrease and increase in plasma EBV DNA after treatment and during tumor progression/ recurrence, respectively. These results suggest the potential utility of circulating cell-free DNA to reveal EBV DNA for the identification of the EBVaGC subtype and/ or for real-time monitoring of tumor progression as well as treatment response in patients with EBVaGC.
掲載誌名
Oncotarget
ISSN
19492553
8
17
開始ページ
28796
終了ページ
28804
並び順
28796
発行日
2017-02-24
備考
Copyright: Shoda et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
EDB ID
325276
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系