ID 110270
タイトルヨミ
ジュウカク シュヨウ ニ タイスル チリョウ センリャク
タイトル別表記
Therapeutic strategy for mediastinal tumors
著者
近藤, 和也 徳島大学大学院ヘルスバイオサイエンス研究部看護学講座臨床腫瘍医療学分野 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
thymoma
thymic carcinoma
p 53
functional tumor
DNA methylation
matrix metalloproteinase
資料タイプ
学術雑誌論文
抄録
Thymoma is the most common tumor of the anterior mediastinum. The rarity of this tumor has somewhat obscured the optimal treatment for this disease. Although the histologic classification of thymoma has remained a subject of controversy for many years, The WHO classification system, which published in 1999, appear to be an advance in our understanding of thymoma. The optimal treatment of thymoma is performed according to its clinical stage. Surgery remains the mainstay of treatment for thymic epithelial tumors. Thymomas also have a high response rate to chemotherapy or radiotherapy. There are several differences between thymoma and thymic carcinoma. Thymoma is a functional tumor, but thymic carcinoma is not. Thymoma has p 53 protein expressions infrequently, and lower incidence of DNA methylation of cancer-related genes comparing with thymic carcinoma. Although thymoma shows cytologically benign, it invades to neighbor organs, disseminates in the thoracic cavity, and rarely metastasizes to the lymph nodes or distant organs. The invasiveness of thymoma is related to increased expression of matrix metalloproteinase and tissue inhibitor of metalloproteinase.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
65
1-2
開始ページ
20
終了ページ
25
並び順
20
発行日
2009-04-25
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
医学系