ID 110413
タイトルヨミ
コツズイ ビショウ カンキョウ ト コツズイシュ ノ シンテン
タイトル別表記
Myeloma progression and bone marrow microenvironment
著者
安倍, 正博 徳島大学大学院医歯薬学研究部血液・内分泌代謝内科学 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
multiple myeloma
MIP‐1
RANK ligand
Wnt
sclerostin
資料タイプ
学術雑誌論文
抄録
Multiple myeloma(MM)develops and expands almost exclusively in the bone marrow, and generates devastating bone destruction. MM cells produce a variety of cytokines, including MIP‐ 1, to stimulate RANK ligand-mediated osteoclastogenesis and extensively resorb bone. Besides enhancing bone resorption, MM cells suppress osteoblastic differentiation from bone marrow stromal cells, leading to extensive bone destruction with rapid loss of bone. The overproduction of inhibitors for the canonical Wingless-type(Wnt)signaling pathway, including DKK‐1, sFRP‐2 and sclerostin, significantly contributes to the suppression of osteoblastogenesis and bone formation in MM. MM cells alter through bone destruction the microenvironment in bone where they colonize, which in turn favors MM tumor growth and survival, thereby forming a progressive vicious cycle between tumor expansion and bone destruction in MM. MM is still difficult to be cured despite the recent implementation of new agents, and its bone disease also remains a significant clinical problem. Further elucidation of the molecular mechanisms of the tumor-bone interactions and tumor growth in the bone microenvironment will provide us with new approaches that have a real impact on both bone disease and tumor progression in MM.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
73
1-2
開始ページ
29
終了ページ
36
並び順
29
発行日
2017-04-25
フルテキストファイル
言語
jpn
著者版フラグ
出版社版
部局
医学系