ID 110634
著者
Ewis, Ashraf A Department of Public Health, The University of Tokushima School of Medicine|Department of Public Health and Occupational Medicine, School of Medicine, El-Minia University
Lee, Juwon Department of Public Health, The University of Tokushima School of Medicine
新家, 利一 Department of Public Health, The University of Tokushima School of Medicine
中堀, 豊 Department of Public Health, The University of Tokushima School of Medicine
キーワード
12 f 2
DFFRY
haplotypes
Japanese
Y-chromosome
資料タイプ
学術雑誌論文
抄録
This study of male-specific genetic markers in the Japanese population was carried out in an attempt to refine the existing theories concerning its population genetics and migration events. We examined the relation between the constructed haplotypes of three biallelic Y-chromosome-specific markers (YAP, 47z and SRY) and the results of studying two other Y-specific polymorphisms of both 12f2 and DFFRY markers. The 12f2 marker was completely absent in 14.7% of Japanese males ; all of them were haplotype II males. None of the Japanese males from other haplotypes or other East Asian populations showed any deletion of 12f2. In all haplotype II Japanese men, we found that DFFRY gene harbors a (C→T) substitution polymorphism that was not found in any other population of this study. These results suggested that although haplotype II Japanese males share with the other haplotype II men from different geographical areas in having the YAP insertion on their Y-chromosomes, their Y-chromosomal structure is somewhat characteristically different. They are probably descendants of the ancestral Jomonese population who lived in Japan before the Yayoi immigrants entered Japan ˜2300 years ago. These findings suggested that linkage studies between Y-specific markers are helpful in understanding the migratory patterns in East Asia. We also suggested that Japanese males have characteristically different Y-chromosomes compared with other populations.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
49
1-2
開始ページ
44
終了ページ
50
並び順
44
発行日
2002
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版