ID 110657
著者
尾崎, 修治 First Department of Internal Medicine, The University of Tokushima School of Medicine
コサカ, マサアキ First Department of Internal Medicine, The University of Tokushima School of Medicine
キーワード
multiple myeloma
biology
treatment
hematopoietic stem cell transplantation
immunotherapy
資料タイプ
学術雑誌論文
抄録
Recently, considerable progress has been made in understanding of the biology and treatment of multiple myeloma. Molecular genetic abnormalities such as bcl-2,c-myc, ras, p53, and Rb genes have been identified in this disease and are related to a poor prognosis. Cytokine studies have revealed that interleukin-6 is a potent growth factor for myeloma cells and is also responsible for the progressive bone resorption together with interleukin-1 βand tumor necrosis factor. Myeloablative chemotherapy followed by allogeneic or autologous hematopoietic stem cell transplantation has increased the incidence of complete remission. However, relapses are still observed because of drug resistance of tumor cells. Immunotherapeutic approaches targeting to cell surface antigens andinterleukin-6 signals are being developed to further eliminate myeloma cells. Translating new biological advances into treatment protocols is essential to improve the prognosis of multiple myeloma.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
44
3-4
開始ページ
127
終了ページ
136
並び順
127
発行日
1998
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版