ID 110659
著者
He, Xiao-bin Second Department of Internal Medicine, The University of Tokushima School of Medicine
イイ, クニオ Second Department of Internal Medicine, The University of Tokushima School of Medicine
六車, 直樹 Second Department of Internal Medicine, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧 KAKEN研究者をさがす
ハヤシ, シゲヒト Second Department of Internal Medicine, The University of Tokushima School of Medicine
伊東, 進 Second Department of Internal Medicine, The University of Tokushima School of Medicine 徳島大学 教育研究者総覧
キーワード
PCNA
gastric cancer
immunohistochemistry
資料タイプ
学術雑誌論文
抄録
Although proliferating cell nuclear antigen (PCNA) is known to be an indicator of malignant potential in tumors, the biological and clinicopathological significance of PCNA in tumor tissue is controversial. Methods : Immunohistochemical expression of PCNA was examined in 58gastric carcinoma tissues obtained at autopsy to test the clinicopathological significance. In addition, in 24 of the 58 tumor tissues we compared immunohistochemical expression of PCNA in biopsy and autopsy specimens from the same patient in order to know whether the proliferating activity of tumor cells is stationary from the early stage to the end of tumor growth. Results : 1. PCNA was undetectable in some tumor tissues (12.5% in biopsy and 10.3% in autopsy specimens). 2. the frequency of PCNA positive cases and labeling index (LI) (%) of PCNA in tumor tissues were not significantly different between biopsy and autopsy specimens. 3. the intensity of PCNA reaction was not related to prognosis. 4. PCNA positive cases and LI did not correlate with survival condition. Conclusion : It is hard to say whether PCNA is a reliable indicator in predicting malignancy and prognosis of gastric cancer.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
44
3-4
開始ページ
149
終了ページ
153
並び順
149
発行日
1998
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系