ID 110674
著者
ウエノ, シュウイチ Department of Psychiatry, The University of Tokushima School of Medicine
キーワード
human serotonin transporter (5-HTT)
human dopamine transporter (DAT1)
functional polymorphism
association study
psychiatric disorders
資料タイプ
学術雑誌論文
抄録
Transporter-assisted uptake of serotonin (5-HT) and dopamine (DA) has been accounted for activities in human behavior or mental status, because they are the sites of action of widely used antidepressant and psychoactive drugs. Both the human serotonin transporter (5-HTT) and human dopamine transporter (DAT1) genes are good candidates for etiological involvement in various psychiatric conditions. The serotonin transporter gene has two types of functional polymorphisms. One is serotonin transporter linked polymorphic region (5-HTTLPR) consisting of length variation of the repetitive sequence containing 20~23-bp-long repeat elements in the 5’-upstream region of the gene. Another polymorphism is that serotonin transporter variable number of tandem repeats(5-HTTVNTR) in its second intron. Both polymorphisms affect the transcription ratio of5-HTT gene and may modify neuronal transmission by changing its protein expression. On the other hand, DAT1 gene has a variable number of tandem repeats type polymorphism(DAT1VNTR) in the 3’-untranslated region of the mRNA, which was also reported to change its gene expression. So polymorphic variations of transporters would change the behavioral and neuropathological tendency. Here, the feature of those two transporters and their relations to psychiatric disorders are described.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
50
1-2
開始ページ
25
終了ページ
31
並び順
25
発行日
2003
EDB ID
フルテキストファイル
言語
eng
著者版フラグ
出版社版