ID 110791
著者
オオツカ, トシヒロ Department of Digestive and Pediatric Surgery, Institute of Health Biosciences ,The University of Tokushima Graduate School
泉, 啓介 Department of Molecular and Environmental Pathology, Institute of Health Biosciences ,The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
徳永, 逸夫 Department of Legal Medicine, Institute of Health Biosciences ,The University of Tokushima Graduate School KAKEN研究者をさがす
後藤田, 貴子 Department of Legal Medicine, Institute of Health Biosciences ,The University of Tokushima Graduate School
イッポウシ, カネシゲ Department of Clinical Pharmacology, Institute of Health Biosciences ,The University of Tokushima Graduate School
滝口, 祥令 Department of Clinical Pharmacology, Institute of Health Biosciences ,The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
カネダ, シンヤ Department of Molecular and Environmental Pathology, Institute of Health Biosciences ,The University of Tokushima Graduate School
佐竹, 宣法 Department of Molecular and Environmental Pathology, Institute of Health Biosciences ,The University of Tokushima Graduate School
大西, 隆仁 Department of Molecular and Environmental Pathology, Institute of Health Biosciences ,The University of Tokushima Graduate School
田代, 征記 Department of Digestive and Pediatric Surgery, Institute of Health Biosciences ,The University of Tokushima Graduate School 徳島大学 教育研究者総覧
島田, 光生 Department of Digestive and Pediatric Surgery, Institute of Health Biosciences ,The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
LEC rat
8-OHdG
glutathione peroxidase
D-galactosamine hydrochloride
Wilson’s disease
資料タイプ
学術雑誌論文
抄録
Repeated injections of D-galactosamine hydrochloride (GalN) increase the survival rate of Long-Evans Cinnamon (LEC) rats, an animal model of Wilson’s disease. The aim of the present study was to investigate the mechanism of GalN for prevention of spontaneous lethal hepatic injury in LEC rats. MaleLEC rats were given a single subcutaneous injection of 300mg/kg of GalN or vehicle (0.9%NaCl) at 14weeks, and killed at 28 weeks of age. Next, 6-week-old male LEC rats were given weekly subcutaneous injections of 300 mg/kg of GalN or vehicle for 3 or 12 weeks, and their hepatic 8-hydroxydeoxy-2’-guanosine (8-OHdG), glutathione peroxidase (GPX), and catalase activities were measured. None of GalN-treated rats died of hepatic injury (0/12), whereas the mortality rate of control rats given 0.9% NaCl was 17% (2/12). GalN administration for 12 weeks decreased the hepatic 8-OHdG, and GalN administration for either 3 or 12weeks increased the glutathione peroxidase activity. GalN administration increased the serum level of alanine aminotransferase, and accelerated megalocytic degeneration of the hepatocytes. GalN treatment is effective in preventing lethal hepatitis in LEC rats and decrease of oxidative DNA damage by GalN plays an important role in increase of the survival rate.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
53
1-2
開始ページ
81
終了ページ
86
並び順
81
発行日
2006-02
EDB ID
161350
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
薬学系
医学系