ID 110795
著者
タケハラ, ヒロオ Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School
イシバシ, ヒロキ Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
ヨシカワ, コウゾウ Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
島田, 光生 Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
Hirschsprung’s disease
intestinal neuronal dysplasia (IND)
HaIND acetylcholinesterase
constipation
endorectal pull-through operation
資料タイプ
学術雑誌論文
抄録
Between 1996 and 2002, 22 cases of Hirschsprung’s disease were treated laparoscopically by endorectal pull-through operation. The proximal margin of the resected bowel materials from these 22 patients were examined histologically by frozen sections at surgery and also after surgery using HampE staining, and complete resection of the aganglionic segment was confirmed. Eleven patients, in whom an informed consent was obtained at randomly, underwent suction biopsy from the pulled-though neorectum after surgery. Of these 11 patients, 2 revealed many AchE-positive nerve fibers in the lamina propria, the muscularis mucosa and around the ganglion cells in the submucosal plexuses. These structural changes were similar to intestinal neuronal dysplasia that was characterized by hyperganglionosis and other neuronal abnormalities. The remaining 9 revealed no AchE activity. Unexpectedly, the two patients showing AchE activity in their neorectum continued to have persistent constipation and were treated with laxatives or glycerin enema. It was suggested that their persistent constipation was caused by intestinal neuronal dysplasia showing an abnormal increase of AchE activity in spite of presence of ganglion cells of the neorectum after surgery, but it was uncertain that they were primary condition as a HaIND or secondary reactions after surgery.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
53
1-2
開始ページ
113
終了ページ
116
並び順
113
発行日
2006-02
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院