ID 110835
著者
Januszewski, Andrzej S University of Melbourne, Department of Medicine, St Vincent’s Hospital
Thomas, Merlin C Baker Institute
Karschimkus, Connie S University of Melbourne, Department of Medicine, St Vincent’s Hospital
Chung, Jasmine S University of Melbourne, Department of Medicine, St Vincent’s Hospital
Rowley, Kevin G University of Melbourne, Department of Medicine, St Vincent’s Hospital
Nelson, Craig L University of Melbourne, Department of Medicine, St Vincent’s Hospital
O’Neal, David N University of Melbourne, Department of Medicine, St Vincent’s Hospital
Dragicevic, George University of Melbourne, Department of Medicine, St Vincent’s Hospital
Harper, Colin A Department of Ophthalmology, University of Melbourne
Best, James D University of Melbourne, Department of Medicine, St Vincent’s Hospital
Jenkins, Alicia J University of Melbourne, Department of Medicine, St Vincent’s Hospital
キーワード
advanced glycation end products
low molecular weight fluorophores
type 1 diabetes
renal function
資料タイプ
学術雑誌論文
抄録
Objectives : Circulating low molecular weight (<10 kDa) fluorophores (LMW-F) measured by non-specific fluorescence spectroscopy may detect small advanced glycation end-products (AGEs) not recognized by other assays. This longitudinal study assessed correlates of LMW-F and predictive power of LMW-F levels for vascular health in Type 1 diabetes (T1DM) patients. Methods : Fasting patients with T1DM (n=37) were studied twice at intervals of 12-60 months (mean±SD, 33±15 months). LMW-F levels were also measured once in 112 healthy control subjects. Results : Relative to controls, LMW-F levels were higher in diabetic subjects at initial and final time points (mean±SD), 5.4±1.9 AU/ml and 4.5±1.8 AU/ml respectively vs. 3.8±2.1 AU/ml p=0.0001 and p=0.06). Baseline LMW-F levels predicted subsequent hs-CRP and oxLDL/LDL values. LMW-F levels decreased significantly over time in diabetes (5.4±1.9 vs. 4.5±1.8 AU/ml p=0.02). Rises in LMW-F levels in individual diabetic subjects correlated significantly with worsening renal function (BUN), glycemia (HbA1c) and with vascular dysfunction (systemic vascular resistance). Conclusions : LMW-F levels predict levels of inflammation and oxidation in T1DM. Changes in LMW-F levels in T1DM reflect variations in glycemia and renal function. Biochemical characterization of LMW-F would facilitate understanding of the potential utility of LMW-F as a therapeutic target.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
55
1-2
開始ページ
29
終了ページ
36
並び順
29
発行日
2008-02
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版