ID 111003
著者
Badr Badr, Hoida Ali Tokushima University
キーワード
Rhamnan sulfate
Methylmercury
Cytotoxicity
Intracellular Ca2+
Lymphocytes
資料タイプ
紀要論文
抄録
Rhamnan sulfate, one of sulfated polysaccharides from seaweeds, is considered to have various characteristics such as antioxidant, anticoagulant, anti-inflammatory, antitumor, contraceptive, and antiviral activities, for the treatment of several diseases. We examined the effect of rhamnan sulfate on thymic lymphocytes treated simultaneously with methylmercury chloride, a toxic organometallic compound, using a flow-cytometric techniques with fluorescent probes, fluo-3-AM (an indicator for intracellular Ca2+) and propidium iodide (an indicator for dead cells). Rhamnan sulfate attenuated the methylmercury-induced increase in cell lethality. This effect of rhamnan sulfate is supposed to be due to the attenuation of methylmercury-induced elevation of intracellular Ca2+ levels. Rhamnan sulfate may be useful for the prevention of organometallic intoxication.
掲載誌名
自然科学研究
ISSN
09146385
cat書誌ID
AN10065859
30
開始ページ
5
終了ページ
8
並び順
5
発行日
2017
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
生物資源系