ID 111082
タイトル別表記
arterial spin labeling法と造影T1強調像の高信号容積の違いが転移性脳腫瘍から神経膠芽腫を区別するのに有用である
ASL for distinguishing GBM from metastasis
著者
ガンボルド, ムングンバガナ 徳島大学大学院医科学教育部(医学専攻)
Khashbat, Delgerdalai Tokushima University
キーワード
arterial spin labeling
perfusion
volumetric analysis
glioblastoma
metastasis
資料タイプ
学位論文
抄録
Purpose : To determine whether differences in tumor volume between arterial spin labeling (ASL) and contrast-enhanced T1-weighted MR images (CE+T1WI) can help differentiate glioblastoma (GBM) from brain metastasis. Materials and methods : Patients with a diagnosis of GBM (n=25) or brain metastasis (n=13) were examined by both conventional and ASL MR imaging. Volumes of interest with high signal intensity on ASL and CE+T1WI were defined using three dimensional analysis software. Tumor volume difference (ASL-CE) and tumor volume ratio (ASL/CE) were obtained. Absolute maximal tumor blood flow (TBF) and TBF ratio (normalized to white matter) were also measured. The Mann-Whitney U test and receiver operating characteristic curve analysis were performed to compare measurements between the tumor groups. Results : Both tumor volume difference and tumor volume ratio were significantly higher in GBM than in metastasis. Both TBF and TBF ratio were higher for GBM than for metastasis, but the differences were not significant. Conclusion : The difference in tumor volume as measured by ASL high signal intensity and CE+T1WI might be useful for differentiating GBM from metastasis, whereas ASL-derived TBF is insufficient.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
64
1-2
開始ページ
58
終了ページ
63
並び順
58
発行日
2017-02
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨:LID201704141003.pdf
論文本文:LID201704141004.pdf
本論文は,著者Mungunbagana Ganboldの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3019号
学位記番号
甲医第1323号
学位授与年月日
2017-03-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
病院