アクセス数 : ?
ダウンロード数 : ?
ID 111083
著者
Oyamada, Takashi Tokushima University
Ogawa, Kazuo Tokushima Bunri University
Nakagami, Hironori Osaka University
Morishita, Ryuichi Osaka University
キーワード
lipoprotein a
atherosclerosis
cardiovascular events
low density lipoprotein
資料タイプ
学術雑誌論文
抄録
Although Lp(a) have been thought to be a cardiovascular risk factor, it is unclear whether lowering Lp(a) levels reduces the risk of cardiovascular diseases. No pharmacological agents which selectively reduce serum Lp(a) levels, and Lp(a) is present in primate but absent in common laboratory animals such as mice and pigs. In the present study we used transgenic mice of human Lp(a) and tested effect a novel Lp(a) lowering drug D-47 on neointima formation after vascular injury. D-47 successfully decreased plasma levels of Lp(a) and possibly inhibited neointima formation in Lp(a) transgenic mice. The results indicate that we can modulate plasma Lp(a) levels by pharmacologic agents and inhibit atherogenic properties of Lp(a) by reducing plasma levels of Lp(a).
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
64
1-2
開始ページ
64
終了ページ
67
並び順
64
発行日
2017-02
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系