ID 111243
著者
Asanoma, Michihito The University of Tokushima
宇都宮, 徹 The University of Tokushima KAKEN研究者をさがす
花岡, 潤 The University of Tokushima
金本, 真美 The University of Tokushima KAKEN研究者をさがす
キーワード
Liver transplantation
regulatory T cells
Foxp3
Transplant immunology
資料タイプ
学術雑誌論文
抄録
Purposes : It is no doubt that regulatory T cells (Foxp3+CD4+CD25+T cells : Treg) play important roles in transplant immunity.We investigated the significance of Treg expression in acute stage of living donorrelated liver transplantation (LDLT) for the possibility of the sensitive marker for immunological state and homeostatic stress after liver transplantation. Methods : Peripheral blood was drawn from 5 recipients of LDLT preoperatively and on post operative 1, 4, 7, and 14 days. The peripheral blood mononuclear cells (PBMCs) were stained with CD4, CD25, Foxp3, and were analyzed with FACScan. This data was compared with clinical output of LDLT. Result : The populations of Treg were significantly decreased in all patients on day 1 after LDLT and significantly increased in patients who had early postoperative complications compared with patients who had no complications. Conclusions : The population of Treg in peripheral blood may reflect the surgical stress such as life-threatening complications after LDLT.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
62
1-2
開始ページ
37
終了ページ
40
並び順
37
発行日
2015-02
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院
医学系