ID 111266
タイトル別表記
2型糖尿病患者における非侵襲的皮下自家蛍光測定の動脈硬化の代替指標としての有用性の検証
Skin Autofluorescence and Atherosclerosis
著者
天満, 仁 徳島大学大学院医学研究科(プロテオミクス医科学専攻)
Horie, Toru Tenma Hospital
キーワード
skin autofluorescence
intima-media thickness
type 2 diabetes
atherosclerosis
資料タイプ
学位論文
抄録
Advanced glycation end-products (AGEs) are thought to play a major role in the pathogenesis of diabetic vascular complications. Skin autofluorescence (AF) was recently reported to represent tissue AGEs accumulation with a non-invasive method. The aim of the present study was to evaluate association between AF value and diabetic vascular complications, such as retinopathy, nephropathy and cervical atherosclerosis using the carotid intima-media thickness (IMT), an established marker of cardiovascular disease in patients with type 2 diabetes. A total of 68 patients with type 2 diabetes were enrolled in a cross-sectional manner. AGEs accumulation was measured with AF reader. Clinical parameters were collected at the time of AF and IMT measurement. Max-IMT was correlated with age and AF (r=0.407, p=0.001), but not with HbA1c, GA, and pentosidine. Also, AF was not correlated with HbA1c, GA and pentosidine, but was correlated with age (r=0.560, p<0.001), duration of diabetes (r=0.256, p<0.05). Multivariate regression analysis revealed that AF, but not age, was an independent determinant of max-IMT. In conclusion, AF might be a beneficial surrogate marker for evaluating carotid atherosclerosis in patients with type 2 diabetes non-invasively.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
62
3-4
開始ページ
126
終了ページ
129
並び順
126
発行日
2015-08
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201505211009.pdf
論文本文 : LID201505211010.pdf
本論文は,著者Jin Temmaの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第2803号
学位記番号
甲医第1245号
学位授与年月日
2015-03-19
学位名
博士(医学)
学位授与機関
徳島大学
部局
先端酵素学研究所
医学系