CR and LCD dietary therapy for diabetic patients : Usefulness of M value

Background: There have been continuing discussion about Calorie Restriction (CR), low carbohydrate diet (LCD) and efficacy of LCD. We have treated lots of diabetic patients and reported clinical significance of LCD and ketone bodies. In current study, Morbus (M) value for blood glucose variability were investigated in CR and LCD, with proposal for usefulness of clinical and research field.
Subjects and Methods: Subjects included 52 patients with Type 2 Diabetes Mellitus (T2DM), which were male 21, female 31, 58.9±12.1 y.o.in average, 60 y.o.in median. They were admitted and provided CR diet (60 % carbohydrates, 1400 kcal/day) on day 1-2, and LCD (12 % carbohydrate, 1400 kcal/day) on day 3-14. Methods were as follows:1) basal biomarkers and daily profile of blood glucose (7 times) on CR were measured on day 2, 2) similarly, glucose profile on LCD were measured on day 4, 3) Triglyceride, uric acid and other markers were measured on day 12. 4) Morbus (M) value in glucose variability was investigated.
Results: By the level of M value, subjects were classified into 4 groups. M value ranged from 13.6 to 425.6 on day 2 (CR) and from 9.0 to 82.1 on day 4 (LCD). The average HbA1c in 4 groups were 6.2 %, 7.0 %, 8.1 %, 9.0 %, respectively. Blood glucose on day 4 was significantly decreased compared with those on day 2 in each group. M value was significantly decreased from day2 to day 4 in group 2, 3, 4. Triglyceride on day 14 was significantly decreased compared with those on day 2 in each group. There was significant correlation between HbA1c and M value on day 2, between average blood glucose and M value on day 2, 4, and between M value of CR and LCD on day 2, 4.
Discussion and Conclusion: The efficacy of LCD was observed from day 2 to day 4, with significant decrease in glucose and M value. The carbohydrate amount was decreased from210g (CR) to 42g (LCD) per day, resulting decrease of average blood glucose and M value. These findings suggest that M-value would be useful marker for treatment of T2DM clinically and research development in glucose variability.

Copyright: © 2017 Bando H, Ebe K, Muneta T, Bando M and Yonel Y. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.