ID 111519
著者
Kusunoki, Masataka Aichi Medical University
Tsutsumi, Kazuhiko Otsuka Pharmaceutical Factory
Nakayama, Meiho Aichi Medical University
Kurokawa, Tsuyoshi Aichi Medical University
Nakamura, Takao Yamagata University
Ogawa, Hitoshi Aichi Medical University
Fukuzawa, Yoshitaka Aichi Medical University
Morishita, Munehiko Aichi Medical University
Koide, Tatsuro Aichi Gakuin University
Miyata, Tetsuro University of Tokyo
キーワード
HOMA-R
PUFA
SFA
Japanese patients
type 2 diabetes mellitus
資料タイプ
学術雑誌論文
抄録
Background : Consumption of polyunsaturated fatty acids (PUFA) improves the lipid metabolism of diabetics, leading to prevents of arteriosclerosis. Exact relationship between saturated fatty acids (SFA) or PUFA and the insulin resistance of diabetics are unknown.
Subjects and Methods : We investigated the relationship between the serum concentrations of saturated and unsaturated fatty acids and the homeostasis model insulin resistance index (HOMA-R) in Japanese patients with type 2 diabetes mellitus.
Results : The SFA, i.e., lauric acid, myristic acid, palmitic acid, and stearic acid ; the monounsaturated fatty acids (MUFA), i.e., palmitoleic acid, oleic acid, and erucic acid ; and the PUFA, i.e., eicosadienoic acid, dihomo-γ-linolenic acid, docosatetraenoic acid, and docosapentaenoic acid were positively correlated with HOMA-R. However, no correlations were found between HOMA-R and SFA, i.e., arachidic acid, behenic acid, and lignoceric acid ; the MUFA, i.e., eicosenoic acid and nervonic acid ; and the PUFA, i.e., linoleic acid, γ-linolenic acid, linolenic acid, 5-8-11 eicosatrienoic acid, arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid.
Conclusions : Some PUFA as well as SFA were positively correlated with HOMA-R. These results indicate that the intake of diet fatty acid must be well balanced in diabetic patients and it is not always true to refrain from taking SFA and increase the unsaturated fatty acids in their diets.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
54
3-4
開始ページ
243
終了ページ
247
並び順
243
発行日
2007-08
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版