ID 111599
タイトル別表記
TRH RELEASE MEASURED BY MICRODIALYSIS
著者
岡内, 泰弘 The University of Tokushima
高橋, 秀夫 The University of Tokushima
溝渕, 樹 The University of Tokushima
板東, 浩 The University of Tokushima KAKEN研究者をさがす
齋藤, 史郎 The University of Tokushima
キーワード
Thyrotropin-releasing hormone (TRH)
Pulsatile secretion
Microdialysis
Hyperthyroidism
資料タイプ
学術雑誌論文
抄録
To measure the thyrotropin-releasing hormone (TRH) release from the hypothalamus in euthyroid and hyperthyroid states, we investigated the changes in TRH levels in the anterior pituitary of conscious male rats using an in vivo microdialysis technique. In the euthyroid rats (n = 18), TRH levels in the extracellular dialysates of the anterior pituitary varied from 1.0 to 101.0 pg/ml in a pulsatile fashion: 15.9 +/- 13.9 (mean +/- SD) pg/ml with 5.8 +/- 1.5 pulses/24 h. In the hyperthyroid rats (n = 5) who received L-thyroxine at 10 micrograms/100 g body weight for 7 days, TRH levels in the dialysates during 6 h was 3.6 +/- 1.7 pg/ml, and significantly lower (P < 0.05) than those of the control rats (15.5 +/- 14.1 pg/ml); the pulse frequency was unchanged. These findings demonstrated for the first time the existence of pulsatile TRH release from the hypothalamus, and showed that thyroid hormone inhibits TRH release by the reduction of pulse amplitude, but not of pulse frequency.
掲載誌名
The Tokushima Journal of Experimental Medicine
ISSN
00408875
cat書誌ID
AA00864027
出版者
School of Medicine, The University of Tokushima
43
3-4
開始ページ
93
終了ページ
100
発行日
1996-12-25
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系