ID 111632
著者
Inoi, Junya Tokushima Municipal Hospital
清水, 一郎 The University of Tokushima
Tsuji, Yasuhiro Tokushima Municipal Hospital
Shibata, Hiroshi The University of Tokushima
キーワード
ursodeoxycholic acid
gallstone
bedtime
cholesterol saturation
資料タイプ
学術雑誌論文
抄録
The administration of a single, daily 600mg dose of ursodeoxycholic acid (UDCA) at bedtime and 3-200 mg doses per day at mealtime was conducted for 6 patients with gallstone and choledocholithiasis who were undergoing biliary drainage for the purpose of improving jaundice. Hepatic bile was collected from a drainage tube after a lapse of time in order to compare the bile acid compositions and cholesterol saturation index (SI) in bile for the 2 protocols. A significant increase in UDCA levels in hepatic bile was observed after both UDCA administration at bedtime and mealtime, but the effect of bedtime administration was significantly greater than that of mealtime administration. Whereas levels of cholic acid and chenodeoxycholic acid (CDCA) decreased for the case of bedtime administration, this was not detected for mealtime administration, although no significant differences among the mean interval values were observed. A significant in difference decreased SI was observed during UDCA bedtime administration, but not during mealtime administration, compared to the SI before administration. This suggests a decreased cholesterol excretion into the bile. Based on these findings and from the point of view of compliance, bedtime administration of UDCA appears to be an effective method.
掲載誌名
The Journal of Medical Investigation
ISSN
13431420
cat書誌ID
AA11166929
出版者
The University of Tokushima School of Medicine
45
1-4
開始ページ
115
終了ページ
122
並び順
115
発行日
1998-08
EDB ID
95044
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系