ID 111689
タイトル別表記
MEN 2B IN JAPAN
著者
Iwahana, Hiroyuki The University of Tokushima
キーワード
MEN 2B
Prognosis
Loss of heterozygosity
資料タイプ
学術雑誌論文
抄録
Since 1968, a total of 23 patients with multiple endocrine neoplasia type 2B (MEN 2B) have been identified in Japan. The mean age at diagnosis was 20.3 years (range, 6 to 39 years). All patients had neuromas and bumpy lips. All patients underwent thyroidectomy for medullary thyroid carcinoma (MTC). Ten of 23 patients had pheochromocytomas. One patient died of cerebral bleeding at the age of 43, 2 patients died of MTC at the age of 35 and 12. Five-, 10-, and 15-year survival rates were 100%, 92%, and 88%, respectively. The clinical course of MTC in MEN 2B in Japanese is not so aggressive when compared with about a 50% 10-year survival reported for Caucasians. Genetic nalysis of 4 MTC and 1 pheochromocytoma from 4 patients with MEN 2B revealed no common changes in regard to loss of heterozygosity on 21 chromosomes or point mutations of the ras, Gsα, or p53 genes.
掲載誌名
Endocrine Journal
ISSN
13484540
09188959
cat書誌ID
AA12020190
AA10901436
出版者
The Japan Endocrine Society
40
6
開始ページ
649
終了ページ
657
発行日
1993
EDB ID
71371
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系
先端酵素学研究所