ID | 111884 |
著者 |
Aihara, Keisuke
Tokushima University
Komiya, Chiaki
Tokushima University
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キーワード | Lactam-bridged peptide
Cyclic peptide
Ring-closing metathesis
Fmoc solid-phase peptide synthesis
Diimide reduction
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資料タイプ |
学術雑誌論文
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抄録 | A new approach has been developed for the synthesis of lactam-bridged cyclic peptides. Following the introduction of N-allyl glutamine and α-allylglycine into the peptide backbone, the side chains of these residues were subjected to a cyclization reaction by ring-closing metathesis (RCM). Reduction of the resulting peptide bearing olefin moiety was achieved using diimide, which was generated in situ from o-nitrobenzenesulfonyl hydrazine and piperidine, gave the corresponding saturated cyclic peptides.
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掲載誌名 |
Tetrahedron
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ISSN | 00404020
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cat書誌ID | AA00861787
AA11539786
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出版者 | Elsevier
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巻 | 71
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号 | 24
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開始ページ | 4183
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終了ページ | 4191
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発行日 | 2015-05-01
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権利情報 | © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
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EDB ID | |
出版社版DOI | |
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言語 |
eng
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著者版フラグ |
著者版
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部局 |
薬学系
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