アクセス数 : ?
ダウンロード数 : ?
ID 111909
著者
Kita, Miku Tokushima University
Yamamoto, Jun Tokushima University
Morisaki, Takuya Tokushima University
Komiya, Chiaki Tokushima University
キーワード
Amide bond cleavage
Hydrogen peroxide
Oxidative stress
Stimulus-responsive
Trimethyl lock
資料タイプ
学術雑誌論文
抄録
Oxidative stress-responsive compounds are attracting significant attention in the field of medicinal chemistry and chemical biology. Here, we disclose the development of a hydrogen peroxide (H2O2)-responsive amino acid that induces peptide bond cleavage in the presence of H2O2 that closely relates to the oxidative stress. The H2O2-responsive amino acid possessing a boronate or boronic acid moiety was incorporated into a peptide using Fmoc-based solid-phase peptide synthesis or that with minor modification, respectively, and the peptide bond cleavage of the obtained peptide was successfully triggered by the addition of H2O2.
掲載誌名
Tetrahedron Letters
ISSN
00404039
cat書誌ID
AA00861801
AA11539822
出版者
Elsevier Ltd.
56
28
開始ページ
4228
終了ページ
4231
発行日
2015-05-21
権利情報
© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
著者版
部局
薬学系