小児滲出性中耳炎でのEndotoxin,Leukotrieneの関与

The endotoxin (Et) and the leukotriene (LT) concentrations in middle ear effusion (MEE) from children suffering from otitis media with effusion (OME) were measured to investigate the correlation between OME and Et/LT.
Significant correlation was noted between the Et concentration and the LTC4 concentration, and also between the Et concentration and the LTD4+LTE4 concentration in MEE (p<0.05).
In the correlation with MEE property, the Et concentration was significantly higher in the seromucoid group (early stage of OME) than in the mucoid group (p<0.05). As regards the correlation with paranasal sinusitis, the Et concentration in MEE was significantly higher in the group complicated with severe paranasal sinusitis than in the group complicated with mild or moderate paranasal sinusitis (p<0.05).
In the correlation with MEE property, the LTD4+LTE4 concentration in the seromucoid group (early stage of OME) was significantly higher than in the mucoid group (p<0.01). As regards the correlation with OME recurrence, the LTD4+LTE4 concentration in MEE in the recurrence group was significantly higher than in the non-recurrence group (p<0.05). The LTD4+LTE4 concentration in MEE was significantly lower in the group administered Oxatomide having anti-LT effect (the Oxatomide-administered group) than in the control group (p<0.05), and the incidence of OME recurrence in the Oxatomide-administered group(18.8%)was almost a half of that in the control group (36.4%).
The above results indicated more Et existence in the middle ear cavity at the early stage of OME and the correlation between its concentration and the severity of paranasal sinusitis and also more LT existence in the middle ear cavity at the early stage of OME and its involvement in the recurrence of OME.