| ID | 111926 |
| 著者 |
Shimizu, Tatsuhiko
Tokushima University
Miyajima, Rin
Tokushima University
Naruse, Naoto
Tokushima University
Yamaoka, Kosuke
Tokushima University
Aihara, Keisuke
Tokushima University
|
| キーワード | C-terminal N-alkylamide
peptide thioacid
dethiocarboxylation
|
| 資料タイプ |
学術雑誌論文
|
| 抄録 | A new synthetic method has been developed to prepare peptides bearing a C-terminal N-alkylamide from peptide thioacids via a radical-initiated dethiocarboxylation process. This method enables the introduction of various alkyl groups to C-terminal amides simply by replacing the amino acid building block. Its application to the preparation of anti-cancer drug ABT-510 is also reported.
|
| 掲載誌名 |
Chemical and Pharmaceutical Bulletin
|
| ISSN | 13475223
00092363
|
| cat書誌ID | AA11695566
AA00602100
|
| 出版者 | The Pharmaceutical Society of Japan
|
| 巻 | 64
|
| 号 | 4
|
| 開始ページ | 375
|
| 終了ページ | 378
|
| 発行日 | 2016-04-01
|
| 権利情報 | © 2016 The Pharmaceutical Society of Japan
|
| EDB ID | |
| 出版社版DOI | |
| 出版社版URL | |
| フルテキストファイル | |
| 言語 |
eng
|
| 著者版フラグ |
出版社版
|
| 部局 |
薬学系
|
