ID 111926
著者
Shimizu, Tatsuhiko Tokushima University
Miyajima, Rin Tokushima University
Naruse, Naoto Tokushima University
Yamaoka, Kosuke Tokushima University
Aihara, Keisuke Tokushima University
キーワード
C-terminal N-alkylamide
peptide thioacid
dethiocarboxylation
資料タイプ
学術雑誌論文
抄録
A new synthetic method has been developed to prepare peptides bearing a C-terminal N-alkylamide from peptide thioacids via a radical-initiated dethiocarboxylation process. This method enables the introduction of various alkyl groups to C-terminal amides simply by replacing the amino acid building block. Its application to the preparation of anti-cancer drug ABT-510 is also reported.
掲載誌名
Chemical and Pharmaceutical Bulletin
ISSN
13475223
00092363
cat書誌ID
AA11695566
AA00602100
出版者
The Pharmaceutical Society of Japan
64
4
開始ページ
375
終了ページ
378
発行日
2016-04-01
権利情報
© 2016 The Pharmaceutical Society of Japan
EDB ID
306227
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
薬学系