ID 112009
タイトル別表記
The acute effects of haloperidol and diazepam on the human VEP (Visual Evoked Potential) and EEG
HLPおよびDZPのVEPおよび脳波への急性効果
著者
吉松, 誠 徳島大学
枝川, 浩二 徳島大学
木原, 章一 徳島大学
三木, 佐知子 徳島大学
生田, 琢己 徳島大学
キーワード
visual evoked potential
EEG
haloperidol
diazepam
資料タイプ
学術雑誌論文
抄録
The acute effects of haloperidol (HLP) and diazepam (DZP) on the Visual Evoked Potential (VEP) and EEG were studied with 16 healthy male subjects (26~43 y.o.). In the two experimental session for each subject, HLP (0.02 mg/kg) were intra-venously and DZP (0.1 mg/kg) were per-orally administered. EEGs and VEPs were recorded through the two derivations (2 ch : O1→A1+2, 5 ch : O1→Cz), with 1024 msec of analysis time, averaging 100 responses. In the experimental session, EEGs and VEPs were recorded before and 15, 30, and 45 min after administration of HLP, before and 30,60, and 90 min after DZP. Consecutive change of group mean VEP were studied. Individual VEPs were subjected to the component analysis, and to the statistical assessment together with EEG. The following results were obtained.
1. After the administration of HLP, the latencies of short, middle and long latency component significantly increased, and the peak-to-peak amplitude N 1-P 2, P 5-N 5 and N 5-P 6 significantly decreased. The largest peak-to-peak amplitude P 4-N 7 significantly increased. In EEG, δ and θ-power% increased, and α2-power% decreased significantly. Significant positive correlation was found between δ, θ-power% of EEG and VEP latencies, and significant negative correlations was found between α2-power% and VEP latencies. These findings indicate the inhibitory effect of HLP all over the visual system through dopaminergic neuron system. The largest peak-to-peak amplitude (P 4-N 7) increased significantly synchronizing with increased θ waves.
2. After the administration of DZP, the latencies of short and middle latency component, P 3 and P 5, increased, P 2 latency decreased significantly. The peak-to-peak amplitude P 3-N 3, N 3-P 4, P 5-N 5, and N 5-P 6 decreased, N 2-P 3 amplitude increased significantly. In EEG, β1-power% increased, and α2-power% decreased significantly. Significant negative correlation was found between δ, θ-power% of EEG and VEP amplitudes, and positive correlations between α2-power% and VEP amplitudes. These findings indicate the inhibitory effect of DZP mainly on lateral geniculate body, optic radiation, and up to the visual cortex making BZD-receptor and GABA-receptor complex. Some exciting effect of DZP before the lateral geniculate body was suggested.
掲載誌名
四国医学雑誌
ISSN
00373699
cat書誌ID
AN00102041
出版者
徳島医学会
53
6
開始ページ
229
終了ページ
241
並び順
229
発行日
1997-12-25
フルテキストファイル
言語
jpn
著者版フラグ
出版社版